Escherichia coli, or E
Common side effects are rash, intestinal gas, vaginal itching or discharge, headache, nausea, vomiting, and diarrhea
ESBL is an enzyme that confers resistance to most beta-lactam antibiotics, including penicillin, cephalosporins, and aztreonam
coli-induced UTIs treatment until other first-line drugs failed to work, based on the fact that gram-negative bacteria was least susceptible to levofloxacin and ciprofloxacin in the sensitivity test both in China and United States (Lu et al
The first plasmid-mediated beta-lactamase in gram-negative bacteria was discovered in Greece in the 1960s
Coli resistance Alternative Fosfomycin3 1 dose Cost ~$60/dose May not be available at some retail phar-macies May consider extending duration to 3-5 Levofloxacin* 250-750 mg QD Uncomplicated Cystitis: 250 mg po QD Uncomplicated Pyelonephritis: 7-day duration:
Options for initial treatment of pyelonephritis or UTI requiring hospitalization include levofloxacin (LVF) or extended-spectrum cephalosporins
This mechanism allows ciprofloxacin to effectively target and eliminate susceptible Systemic fluoroquinolones, including levofloxacin, associated with disabling and potentially irreversible serious adverse reactions (e
E
This drug is widely used in outpatient and inpatient healthcare settings due to its favorable safety and efficacy profile
Based on one included trial and pharmacological research, we raised hypothesis that levofloxacin was superior to ciprofloxacin for treatment of E
coli are common in some communities; therefore, quinolones should not be used unless hospital surveys indicate more than 90 percent susceptibility of E